Guide to Flea and Tick Medication - Ask A Vet

The Pet Collective Cares · 13 years ago

🛒 Get items mentioned in this video

What is the difference between Frontline Plus and Advantage?

Frontline Plus uses fipronil, which absorbs into skin oils and becomes waterproof, killing both fleas and ticks. Advantage contains imidacloprid and other agents that kill fleas, eggs, and larvae by preventing eggs from hatching and larvae from developing into adults.

At a glance

Length
9 min
Channel
The Pet Collective Cares
Video from
Jul 2013
Rating
⭐⭐ Great video · 2/2
Best for
Pet owners choosing flea and tick prevention for dogs or cats

What this video answers

  • What is the difference between Frontline Plus and Advantage?
  • Why would a veterinarian recommend Revolution for cats?
  • Can I use flea prevention and oral medication together?
  • Why don't flea collars work as well as other products?
  • What should I do if I see adult fleas while using Sentinel?
Reads the guide aloud in your browser — free, no account.

Overview of Flea and Tick Prevention Products

Dr. Courtney Campbell DVM walks through the landscape of flea and tick medications available to pet owners, explaining how different products work and which situations call for which treatments. The video cuts through marketing confusion by focusing on how each medication targets parasites—whether by killing adult fleas, preventing eggs from hatching, or protecting against multiple parasites at once. Understanding these categories helps pet owners make informed decisions with their veterinarian rather than guessing which product suits their pet's lifestyle and risk factors.

The timing and geography of flea prevention matter more than many owners realize. In warm climates like Southern California, fleas remain a year-round threat, while colder regions may only need seasonal protection. Dr. Campbell emphasizes a critical safety rule: never use dog flea medications on cats or vice versa, as the dosages and active ingredients can cause serious toxicity. The video reviews spot-on treatments, oral medications, shampoos, and collars—each with distinct pros and cons depending on your pet's exposure and infestation level.

Key Moments

Key Points About Flea and Tick Medications

  • Flea prevention needs depend on climate and geography; warm regions require year-round protection while colder areas may need it seasonally.
  • Never apply a dog medication to a cat or vice versa—cross-species use can cause severe toxicity and illness.
  • Spot-on treatments like Frontline Plus and Advantage work by absorption into skin oils, offering lasting protection but should not be applied around bathing times.
  • Oral medications fall into two types: those killing adult fleas within hours (like Comfortis and Capstar) and those preventing eggs and larvae from maturing (like Sentinel).
  • Flea shampoos provide rapid kill for severe infestations but lack residual activity beyond 24–48 hours, making them unsuitable for long-term prevention.
  • Indoor-only pets still need flea prevention because parasites hitch rides indoors on clothing and shoes.
Featured image for the guide to Guide to Flea and Tick Medication - Ask A Vet by The Pet Collective Cares

Why Pet Flea and Tick Control Matters for Every Owner

Fleas and ticks are more than a nuisance—they spread serious diseases like Lyme disease and pose health risks to both pets and people. Many owners mistakenly believe indoor-only pets don't need protection, but flea eggs and parasites easily enter homes via human clothing and footwear, meaning even a house cat can become heavily infested without visible outdoor exposure. By choosing the right prevention strategy for your pet's specific risk profile—indoor versus outdoor, local tick prevalence, infestation severity—you protect their health year-round and prevent the need for emergency treatments. A brief conversation with your veterinarian about your pet's actual exposure ensures you're investing in effective prevention rather than over- or under-protecting.

Frequently Asked Questions About Flea and Tick Medications

What is the difference between Frontline Plus and Advantage?

Frontline Plus uses fipronil, which absorbs into skin oils and becomes waterproof, killing both fleas and ticks. Advantage contains imidacloprid and other agents that kill fleas, eggs, and larvae by preventing eggs from hatching and larvae from developing into adults. Advantage is particularly effective for flea control, while Frontline Plus covers both fleas and ticks.

Why would a veterinarian recommend Revolution for cats?

Revolution (containing selamectin) protects against fleas, ticks, heartworms, intestinal parasites, ear mites, and skin mites in one monthly application. Dr. Campbell finds it especially valuable for cats because indoor-outdoor cats may encounter multiple parasites during neighborhood exploration, and one product covers the full spectrum of threats cats face.

Can I use flea prevention and oral medication together?

Yes—in severe cases, oral medications like Comfortis can be used alongside spot-on treatments like Frontline Plus. However, this combination should only be done under veterinary guidance. Products like Sentinel and Capstar are designed to work within a broader prevention plan and are very safe when used as directed.

Why don't flea collars work as well as other products?

Flea collars have two main limitations: they only work effectively near the collar (local protection rather than full-body), and they lack residual activity, lasting only one to two weeks compared to the full month offered by spot-on or oral treatments. Some older collars can also be toxic to pets or people who handle them.

What should I do if I see adult fleas while using Sentinel?

Sentinel prevents flea eggs and larvae from developing, not adult fleas. If an adult flea jumps on your pet, you may see it, but any eggs or larvae it produces will never mature. The product completes flea prevention by breaking the life cycle, even if occasional adults appear. For immediate adult flea kills, Capstar works within 30 minutes.

A still from the video Guide to Flea and Tick Medication - Ask A Vet by The Pet Collective Cares
See all funny videos →

Gear & products featured here

As an Amazon Associate we earn from qualifying purchases.

See the BEST NEW products on Amazon!

Key Terms

Insect growth regulator (IGR)
A medication that prevents flea eggs from hatching or larvae from developing into adult fleas, breaking the reproduction cycle.
Fipronil
The active ingredient in Frontline Plus that absorbs into skin oils, becomes waterproof, and kills fleas and ticks.
Imidacloprid
The active ingredient in Advantage that kills adult fleas and prevents eggs and larvae from maturing.
Residual activity
How long a flea or tick medication remains effective on your pet's skin after a single application.
Selamectin
The active ingredient in Revolution that protects against multiple parasites including fleas, ticks, heartworms, and mites in one dose.

Sources: Insect growth regulator (IGR) · Fipronil · Imidacloprid · Residual activity · Selamectin — definitions cross-referenced with Wikipedia

Justin’s Take

This video is genuinely helpful because it explains how different flea medications actually work rather than just listing brand names. Dr. Campbell avoids recommending a single "best" product and instead teaches you how to think about your pet's individual risk—climate, lifestyle, infestation severity—so you can have an informed conversation with your own veterinarian.

I especially appreciated the warning about never mixing dog and cat medications; it's a straightforward safety rule that could prevent serious illness, yet many pet owners don't know it. The explanation of how Sentinel prevents the flea life cycle without killing adults also clarifies a common source of confusion. If you're overwhelmed by flea prevention options at the pet store, this video cuts through the noise and teaches you to ask the right questions. Highly worth watching before your next vet visit.

Great video · 2 out of 2

Justin
Justin

I started Helicopterstour.com because I genuinely believe there’s no better way to see the world than from the sky. I used to work on the Pride of America cruise ship in Hawaii, helping guests book shore excursions all over the islands. Two Vacation Hero Awards 2,000+ Guests/Week Pride of America · NCL Hawaii Shore Excursions 1000+ Tours Reviewed

Video by The Pet Collective Cares on YouTube. If you enjoyed it, please subscribe to their channel and show your support for the great video.

Description

Dr. Courtney Campbell DVM cuts through the confusion about flea and tick medications.
Subscribe to The Pet Collective-Cares http://bit.ly/TPCCARESUB
Website: http://www.thepetcollective.tv
Facebook: http://www.facebook.com/thepetcollective
Twitter: https://twitter.com/petcollectiveTV
Pinterest: http://pinterest.com/petcollectivetv/
Google+: http://gplus.to/thepetcollective

What is the best flea and tick medication and how often do you really need to apply it?

In this episode, find out the answers to the frequently asked questions about flea and tick medication. You might be surprised by Dr. Campbell's thoughts.

Special thanks to the Animal Medical Center of Southern California

Host: Courtney Campbell, DVM

Coordinating Producer: Dawn Poomee
Editor: Shawn McPherson

Video transcript for “Guide to Flea and Tick Medication - Ask A Vet” Accessibility

A full written transcript of this video, provided for accessibility. Select any timestamp to jump the video to that moment.

There is a myriad of different flea and tick prevention medications. Let's cut through the confusion and talk about it. [Music] Today we're going to talk about how to keep your pet free of those pesky parasites that are outdoors. This can be very simple to do and keep your pet

really safe. Fleas and ticks tend to be seasonal. In colder climates, you may not have to use flea prevention as frequently, but let's say in Southern California, where I happen to be right now, flea prevention is absolutely essential because it's warmer down here and therefore it's literally flea season

all year round. One of the products I like to talk about is Advantage. This product actually has imidoprit. Now, it also has some other medications in there that keep your pet free from fleas, flea eggs, and flea larae. This is what I might call an insect growth regulator in the sense that it does prevent eggs from

hatching and larae from becoming adult fleas. This does kill adult fleas as well. So, this particular product, as you can see by the picture, is for cats. You do not want to use a medication designed for dogs on cats and vice versa. There are toxicities that exist that can make cats and dogs extremely

sick. In other words, use a cat product for a cat and a dog product for a dog. Don't ever mix the two. Second product that I personally like too is Frontline Plus. Now, this product is really fast acting. It kills fleas and ticks together. What's interesting about fripronil as a product is it's absorbed

into the fat of the skin. Therefore, it is essentially waterproof. But the truth is we know that frequent bathing can disturb the efficacy of this product. I would suggest do not bathe 2 days before application of this product and 2 days after application of this product. Another product that I particularly like

for cats especially is a product called Revolution. In this particular product, it has a medication in it called Celctin. This will protect dogs and cats alike, but I personally really like it for cats. I think it's highly effective. It protects against fleas, ticks, heartworms, intestinal parasites, some

ear mites, and some skin mites all from one product. Now, these are all potential parasites that your cat, maybe indoor, outdoor, may come in contact with as they go and inspect the neighborhood and just enjoy the outside life. So, keep your cat protected with once a month revolution. One product

that is very similar to Frontline, I like to call it a high-powered Front Line, is this particular product called Certifect. This has the same product that's in frontline which is called fippron but it also has methoprne and amitraz in it. Now methoprne and amitraz both of them can kill ticks very fast.

So, if you have a dog or a cat who is in contact with a lot of ticks or in an area where there's a lot of ticks, you may want to consider Certifect because this will keep your dog protected against ticks, which can spread deadly Lyme disease. Result tickics. This is strictly for ticks, not for fleas, and

it is for rapid killing of ticks. It's actually just a spot-on application. You see a tick, take the product out, spray it on. The tick will die in three hours. If it falls off, you probably want to discard of that tick somewhere else so that the tick is not consumed. But again, this is a spot-on rapid kill

product for ticks. Now, flea shampoos are great for severe infestations. They produce a very rapid kill, and they get fleas off of your pet immediately. But what do they lack? Residual activity. So they don't really last longer than 24 hours, maybe 48 hours. And anything longer than that, you're really

stretching the efficacy of this product. So again, flea shampoos certainly have their place in rapidly killing a lot of fleas, but they don't last very long. Let's talk about some really popular products that people really seem to like. One product that people really seem to like is something called a flea

collar. Now, flea collars can be effective in some cases, but here's some disadvantages of the flea collar. First, the flea collar tends to be only effective locally. That means where you apply it, that's the only place it's generally going to work. Second, it doesn't have a lot of residual activity.

For instance, some of the products I just talked about last up to one month. Flea collars may last a week to two weeks max. Second thing is sometimes they can be toxic to your dog. Sometimes they can be toxic to people who touch because a lot of times the product is actually on the

hair. So flea collars, I wouldn't necessarily pick them as my first choice. I would pick something that has long residual activity, like his spot-on treatment, and I know has been tested and is effective. Now, we're on to oral medications. This is where it gets interesting because some of these

products only last for 24 hours so that it kills fleas very rapidly and some last a whole month. The first product I'd like to talk about is Capstar. I like this product because it works and it's safe. This is a great product to use if you have your pet who is severely infested with fleas or let's say you

rescue a dog who is severely infested with fleas. You know that immediately once you give this product it will start killing adult fleas in 30 minutes. And it lasts about 24 hours, sometimes up to 48 hours. And so Capstar, not only is it extremely safe, but it's also very effective. Another product that I really

like to use in certain situations is Sentinel. Now, Sentinel is great against heartworms and fleas. Now, the way it kills fleas is interesting. It's classified kind of as an IGR, insect growth regulator. That means it targets a specific part of the flea life cycle. It prevents hatching of eggs and it also

prevents larae from becoming adult fleas. You give this product and it prevents fleas for the whole month. Now, some people might say, "Doc, I gave my dog Sentinel, but I still see adult fleas." Well, Sentinel kills flea eggs and larae. That means if adult jumps on your dog, you may see that adult. That

adult may lay eggs and larae, but again, those eggs and larae are never going to mature, thus completing the life cycle. Two products that I really like to use for flea prevention are Comfortis and Trifecus. Now again let me repeat all these products do target a specific part of the flea life cycle. These two

products actually target the adult flea and so they start killing fleas within 4 hours after giving it and it lasts for 30 days. Trifectus actually combines another product to prevent heartworms and some intestinal parasites like round worms, hookworms and whipworms. While Comfortis just is focused on the flea.

These products are super safe and in severe cases can actually be used in conjunction with Frontline or any of the spot-on treatments. So, you have three categories of products when it comes to flee and tick control. The spot-on applications, your collars and shampoos, and then your

oral tablets. Talk with your veterinarian about what would be best for your pet because all of it is determined upon your pet's risk. For instance, some might say, "Doc, my pet is indoor only. My dog is indoor. My cat is indoor. I don't need flea prevention." Remember, fleas hitch a

ride on our clothes and our shoes and everything. That's why an indoor cat can be loaded with fleas without you knowing it. So, every pet needs to be protected. And it's important to have a really thorough conversation with your veterinarian about what would be great for your pet.

You're watching the Pet Collective Cares. Want to see more of Ask a Vet? Then don't forget to subscribe. [Music]

How videos are chosen here

Every video on Helicopterstour.com is hand-picked and reviewed by Justin — nothing is added automatically. Each one gets an original written guide and an honest rating: ⭐ 1 out of 2 means a good video worth your time, and ⭐⭐ 2 out of 2 means a great one we would recommend to anyone. The videos belong to their creators — every page links back to the original channel so you can subscribe and support them.

Contact us

Get new videos in your inbox

A short email when we publish something new. No spam — unsubscribe anytime.